Urticaria Pigmentosa (UP)
People with UP can have discoloured and itchy skin. Mast cells are a type of immune cells. In UP, there are many mast cells on the skin, which give out histamine resulting in the dark rashes or hives, especially when the skin is rubbed.
This condition can be seen in all age groups but usually in infants or children.
Sometimes the mast cells may affect the rest of the body causing allergic symptoms.
Diagnosis can be confirmed with a skin biopsy.
Treatment is with antihistamines when needed and avoidance of certain histamine-containing food.
Bullous Congenital Ichthyosiform Erythroderma (BCIE) or Epidermolytic Hyperkeratosis (EHK)
Children with this condition have peeling skin and blisters at birth. The skin then becomes red with erosions.
Scaly, dry, red, raw and thickened skin may develop later on.
There is a higher risk of skin infection as the normal skin barrier is disrupted.
This is caused by an abnormality in the skin proteins (Keratin 1 and 10).
Treatment is with emollients and a medication similar to Vitamin A in severe cases.
Autosomal Recessive Congenital Ichthyosis (eg. Lamellar or Harlequin Ichthyosis)
Due to mutations in genes encoding the formation of skin cells, these babies are born with a thick membrane encasing their skin.
As the skin is tight, the movement of the chest wall, eyes, mouth, fingers and toes may be affected.
They then develop large, brown and thick scales. There can be a higher risk of skin infection.
Treatment is with emollients and a medication similar to Vitamin A.
FUNDING FOR CHILDREN UNDER 18 YEARS OLD
This special fund is available for children under the age of 18 years around the world affected with ichthyosis and is intended to provide financial assistance to purchase lotions, medicine, and treatment necessities.(Click to learn more)
The skin, hair and immune system are affected in people with Netherton syndrome.
They have red, itchy, scaly skin with sparse and brittle hair. Itch is a frequent problem.
They can also have problems regulating their temperature. Teeth growth can be affected.
There can be poor weight gain and food allergies, asthma and eczema.
This is a genetic syndrome which can result in skin, eyes, teeth and brain abnormalities.
The abnormal gene is located at the gene which encodes for gender. Females with an abnormal copy of the gene will get this condition. They can have vesicles at birth, which then become warty.
The affected skin then becomes more pigmented before becoming lighter than the usual skin tone.
The dentist, eye doctor and neurologist may also participate in the care of affected.
Are a group of blood vessel conditions that may present at birth or in the first few weeks or months of life. Sometimes they may even present after a few years.
Categorized into 2 broad groups, vascular tumours and malformations range from mild to severe conditions.
While most cases are isolated, some may be associated with other organ abnormalities such as the brain, spine, eye, heart and/or bones that can lead to significant physical, psychological and emotional impairment.
The more complex cases will require multi-disciplinary treatment in centres specialising in the management of complex vascular anomalies.